{"created":"2023-06-19T07:30:38.531553+00:00","id":601,"links":{},"metadata":{"_buckets":{"deposit":"91e1d770-c5d1-4536-9c98-6f22aeebe995"},"_deposit":{"created_by":3,"id":"601","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"601"},"status":"published"},"_oai":{"id":"oai:nodai.repo.nii.ac.jp:00000601","sets":["47:48:132:133"]},"author_link":["3584","3583","3585","3587","3580","3572","3573","3574","3586","3577","3576","3582","3578","3579","3581","3575"],"item_1_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"31","bibliographicVolumeNumber":"61","bibliographic_titles":[{}]}]},"item_1_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ニンニクに含まれるアリシンはヒトで運動誘発性インターロイキン（IL）6産生を抑制することが報告されている。しかし，アリシンは特有の強い臭気を持つため，実生活を考えると日常的に使用することが難しい。我々はそこで，無臭ニンニク（odorless garlic ; OG）2か月間摂取が運動誘発性IL-6産生と他の免疫応答を減弱する可能性について検討することを目的とした。日頃からあまり活動的でない6名の健康な男性（22.0±0.7歳）を対象に一日当たり1 gのOGを2か月間にわたって摂取させた。研究での運動負荷条件は推定最大心拍数の80％強度の自転車運動とし，45分間実施した。運動負荷は，実験開始前（control群 ; CON-Ex）とニンニク摂取2か月後（odorless garlic supplementation and exercise群 ; OG-Ex）に実施した。血液サンプルは運動負荷を行う前，運動負荷直後（0 min），30分後，60分後に採取し，IL-6，IL-10，白血球数，好中球数，リンパ球数，Natural Killer Cell Activity （NKCA），コルチゾールを測定した。運動負荷前から運動負荷60分後までの上昇曲線下面積（iAUC）を算出し，統計解析には繰り返しのある二元配置分散分析（ANOVA）およびHolm’s methodを用いた対応のあるt検定を行った。運動負荷前の生化学値にはCON-ExとOG-Exの間に有意な差は見られなかった。運動負荷後の白血球数，好中球数，リンパ球数，NKCA，IL-10，およびコルチゾールに交互作用は見られなかったものの，IL-6には交互作用が見られた（p＝0.011）。OG-Ex 群の運動誘発性IL-6 iAUC値はCON-Ex群に比べて有意な低下がみられた（CON-Ex, 82.5±12.2 min･pg/mL ; OG-Ex, 55.5±14.2 min･pg/mL ; p＝0.018）。今回の結果は2か月間のOG摂取が運動誘発性IL-6上昇を抑制するという仮説を支持する結果となった。しかしながら，OG摂取は他の免疫指標に影響を及ぼすことはなかった。OG摂取が運動誘発性の免疫機能に及ぼす影響については，今後のさらなる研究が必要である。","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Allicin, which is a primary compound in crushed garlic, inhibits exercise-induced interleukin (IL)-6 production in humans. However, the daily use of crushed garlic or stabilized allicin is not practical due to the strong odor of allicin. We therefore investigated the possibility that odorless garlic (OG) supplementation for 2 months attenuates exercise-induced IL-6 and other immunological responses. Six healthy untrained men (aged 22.0±0.7 years) consumed 1 g of OG per day for 2 months. Participants underwent two 45-min periods of acute cycling exercise at 80% intensity of heart rate reserve (HRR). The first period was at baseline (control exercise ; CON-Ex) and the second after 2 months of OG supplementation (odorless garlic supplementation and exercise ; OG-Ex). To assess levels of IL-6, IL-10, leukocytes, neutrophils, lymphocytes, Natural Killer Cell Activity (NKCA) and cortisol, blood samples were collected before and immediately (0 min), and 30 and 60 min after each 45-min period of exercise. Two-way repeated measures analysis of variance (ANOVA) and paired t-test with Holm’s method were performed, and the incremental area under the curve (iAUC) from before to 60 min after exercise was calculated. No significant differ­ences in the pre-exercise levels of biochemical indices were observed between the CON-Ex and OG-Ex assessments. No significant interaction effects were observed in exercise-induced changes in leukocytes, neutrophils, lymphocytes, NKCA, IL-10, or cortisol. A significant interaction effect was observed in exercise-induced changes in IL-6 (p＝0.011). OG consumption also significantly decreased the iAUC of IL-6 (CON-Ex, 82.5±12.2 min･pg/mL ; OG-Ex, 55.5±14.2 min･pg/mL ; p＝0.018). Our findings support the hypothesis that two months of OG supplementation attenuates exercise-induced increases in IL-6 levels among untrained men. However, OG did not exert a similar effect on other immunological parameters. Further study is required to clarify the effect of OG on exercise-induced activation of the immune system.","subitem_description_type":"Other"}]},"item_1_description_13":{"attribute_name":"レポート・講演番号","attribute_value_mlt":[{"subitem_description":"E","subitem_description_type":"Other"}]},"item_1_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"4","subitem_description_type":"Other"}]},"item_1_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_1_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00164184","subitem_source_identifier_type":"NCID"}]},"item_1_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"東京農業大学大学院農学研究科食品栄養学専攻|日本学術振興会特別研究員"},{"subitem_text_value":"富士産業株式会社"},{"subitem_text_value":"日本体育大学運動生理学研究室"},{"subitem_text_value":"富士産業株式会社"},{"subitem_text_value":"富士産業株式会社"},{"subitem_text_value":"東京農業大学応用生物科学部栄養科学科"},{"subitem_text_value":"東京農業大学応用生物科学部栄養科学科"},{"subitem_text_value":"東京農業大学応用生物科学部栄養科学科"}]},"item_1_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture|Research Fellow of the Japan Society for the Promotion of Science"},{"subitem_text_language":"en","subitem_text_value":"Fuji Sangyo Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Department of Exercise Physiology, Nippon Sport Science University"},{"subitem_text_language":"en","subitem_text_value":"Fuji Sangyo Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Fuji Sangyo Co., Ltd."},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"},{"subitem_text_language":"en","subitem_text_value":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture"}]},"item_1_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ムシュウ　ニンニク　2カゲツカン　ノ　セッシュ　ハ　ウンドウ　ユウハツセイ　IL-6　ジョウショウ　ヲ　ヨクセイ　スル：ゼンゴ　ヒカク　シケン"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"砂見, 綾香"},{"creatorName":"スナミ, アヤカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田村, 弘司"},{"creatorName":"タムラ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須永-坂牧, 美歌子"},{"creatorName":"スナガ-サカマキ, ミカコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"草野, 崇一"},{"creatorName":"クサノ, シュウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"児玉, 俊明"},{"creatorName":"コダマ, トシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"多田, 由紀"},{"creatorName":"タダ, ユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"日田, 安寿美"},{"creatorName":"ヒダ, アズミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川野, 因"},{"creatorName":"カワノ, ユカリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunami, Ayaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunaga-Sakamaki, Mikako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusano, Shuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tada, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hida, Azumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawano, Yukari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3587","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-08"}],"displaytype":"detail","filename":"61_31.pdf","filesize":[{"value":"468.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"61_31","url":"https://nodai.repo.nii.ac.jp/record/601/files/61_31.pdf"},"version_id":"312b4046-2baa-4d8d-a859-72a1be89feef"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"免疫応答","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"自転車運動","subitem_subject_scheme":"Other"},{"subitem_subject":"immunological responses","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cycling exercise","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"無臭ニンニク2か月間の摂取は運動誘発性IL-6上昇を抑制する：前後比較試験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"無臭ニンニク2か月間の摂取は運動誘発性IL-6上昇を抑制する：前後比較試験"},{"subitem_title":"Odorless Garlic Supplementation for Two Months Attenuates Exercise-induced Increases in Interleukin-6 : A Before and After Comparison Study","subitem_title_language":"en"}]},"item_type_id":"1","owner":"3","path":["133"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-08"},"publish_date":"2016-07-08","publish_status":"0","recid":"601","relation_version_is_last":true,"title":["無臭ニンニク2か月間の摂取は運動誘発性IL-6上昇を抑制する：前後比較試験"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T08:01:22.640650+00:00"}