@article{oai:nodai.repo.nii.ac.jp:00000476, author = {木島, 愛美 and 増田 宏司 and 佐々木 剛 and 土田 あさみ and 大石 孝雄 and Manami, Kijima and Koji Masuda and Takeshi Sasaki and Asami Tsuchida and Takao Oishi}, issue = {1}, month = {2016-04-20}, note = {本研究ではイヌの行動特性関連候補遺伝子としてBDNF遺伝子に着目した。多型検索を行った結果,6箇所の一塩基多型(SNPs;-2452G>C,-2439A>T,-2260T>C,-139C>T,-72G>Aおよび60C>A)が特定され,-2452G>C多型と-2439A>T多型,-72G>A多型と60C>A多型の間でそれぞれ高率な連鎖が確認された。また,-72G>Aおよび同義置換であることが推測された60C>Aについては,活動性-恐怖性スコアとの間に有意な関連が認められた。, The present study demonstrated polymorphism screening of canine brain derived neurotrophic factor gene as one of behavioral trait relatives. We identified six novel single nucleotide polymorphisms (SNPs ; -2452G>C, -2439A>T, -2260T>C, -139C>T, -72G>A and 60C>A), -2452G>C and -2439A>T were highly linked as well as -72G>A and 60C>A. The statistical analyses revealed that and the -72G>A and 60C>A (60C>A as synonymous mutation), were significantly associated with `activeness-fearfulness discrimination scores'., E, 8, KJ00007967219, 論文, Article}, pages = {71--77}, title = {イヌ脳由来神経栄養因子(BDNF)遺伝子の多型検索および一塩基多型(-72G>A,60C>A)と活動性─恐怖性スコアとの関連性}, volume = {57}, year = {}, yomi = {キジマ, マナミ and マスダ, コウジ and ササキ, タケシ and ツチダ, アサミ and オオイシ, タカオ} }