{"created":"2024-11-26T06:16:49.448837+00:00","id":2000343,"links":{},"metadata":{"_buckets":{"deposit":"1ed0ddc7-f8ab-44b9-b4d3-46412033da5d"},"_deposit":{"created_by":15,"id":"2000343","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000343"},"status":"published"},"_oai":{"id":"oai:nodai.repo.nii.ac.jp:02000343","sets":["1:1725514214360"]},"author_link":[],"control_number":"2000343","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"12","bibliographicPageStart":"1","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"50％エタノールおよびヘキサンで抽出したウコンの精油成分をNASHモデルらとに投与した結果、肝脂肪化および線維化が抑制されることが確認された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"\"In this study, the fraction extracted from turmeric powder with 50% ethanol and fractionated with\nn-hexane were administered to diet-induced NASH model rats. NASH model was prepared with SD\nrats by feeding an originally designed choline-deficient, high-fat, high-fructose (HFF-CD) diet for\n10 weeks. To the HFF-CD diet, hexane fraction and 50% ethanol fraction after hexane fractionation\nwere added at 100 mg/kg body weight. 10 weeks later, blood samples and liver were collected for the\nfollowing parameters: lipid weights, serum ALT, AST, TG, liver TG, TBARS levels, lipid metabolismrelated\ngene expression and histopathological examination of the liver. As the results, the hexane\nfraction and 50% ethanol fraction showed a decrease in lipid weight, a decrease in hepatic TG,\nand activation of PPAR-α in the lipid metabolism-related gene test. These results suggest that the\nhexane fraction of turmeric has an inhibitory effect on fat accumulation in the liver by promoting lipid\nmetabolism in NASH model rats.\"","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-023-47097-6","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of Agriculture,","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yukari, Watanabe","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of Agriculture","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hitoshi, Watanabe","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Tokyo University of Agriculture","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sarasa, Kogure","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of Agriculture,","affiliationNameLang":"en"},{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of Agriculture"},{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Tokyo University of Agriculture"}]}],"creatorNames":[{"creatorName":"Yuri, Tanioka","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of Agriculture","affiliationNameLang":"en"},{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Tokyo University of Agriculture"}]}],"creatorNames":[{"creatorName":"Jun, Yamauchi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Ecological Symbiotic Science, Graduate School of Agriculture, Tokyo University of Agriculture,","affiliationNameLang":"en"},{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Graduate School of Agriculture, Tokyo University of Agriculture"},{"affiliationName":"Department of International Food and Agricultural Science, Faculty of International Agriculture and Food Studies, Tokyo University of Agriculture"}]}],"creatorNames":[{"creatorName":"Tadasu, Furusho","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-11-26"}],"filename":"10284019_出版者版_20240820174132.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nodai.repo.nii.ac.jp/record/2000343/files/10284019_出版者版_20240820174132.pdf"},"version_id":"bb759d08-057b-4806-b478-fc0e66908307"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウコン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Turmeric","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"精油成分","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Essential oil components","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"非アルコール性脂肪肝炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-alcoholic steatohpatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NASH","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["1725514214360"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-11-26"},"publish_date":"2024-11-26","publish_status":"0","recid":"2000343","relation_version_is_last":true,"title":["Essential oil components of turmeric inhibit hepatic lipidification and liver fibrosis in a diet-induced NASH model rats"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-11-26T06:38:37.239250+00:00"}