{"created":"2024-07-29T00:14:33.602857+00:00","id":2000281,"links":{},"metadata":{"_buckets":{"deposit":"b54846e4-78ce-40bf-8b99-32d6a7ecc893"},"_deposit":{"created_by":15,"id":"2000281","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000281"},"status":"published"},"_oai":{"id":"oai:nodai.repo.nii.ac.jp:02000281","sets":["1:1721958258155"]},"author_link":[],"control_number":"2000281","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-05-15","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Frontiers in Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The global obesity epidemic is a significant public health issue, often leading to metabolic disorders such as diabetes and cardiovascular diseases. Collagen peptides (CP) and their bioactive component, Prolyl-hydroxyproline (Pro-Hyp), have shown potential in reducing adipocyte size, with unclear mechanisms concerning brown adipocyte differentiation.Methods: We investigated the effects of Pro-Hyp on the differentiation of brown adipocytes in C3H10T1/2 mesenchymal stem cells, focusing on its impact on adipocyte size, gene expression related to brown fat function, and mitochondrial activity.Results: Pro-Hyp treatment decreased adipocyte size and upregulated brown fat-specific genes, including C/EBPα, PGC-1α, and UCP-1. Remarkably, it did not alter PPARγ expression. Pro-Hyp also elevated mitochondrial activity, suggesting enhanced brown adipocyte functionality. A Pro-Hyp responsive element was identified in the PGC-1α gene promoter, which facilitated the binding of the Foxg1 transcription factor, indicating a novel regulatory mechanism.Conclusion: Pro-Hyp promotes brown adipocyte differentiation, potentially offering a therapeutic strategy for obesity management. This study provides a molecular basis for the anti-obesity effects of CP, although further in vivo studies are needed to confirm these findings and to investigate the potential impact on beige adipocyte differentiation.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fnut.2024.1375532","subitem_relation_type_select":"DOI"}}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"},{"affiliationName":"Department of Molecular Microbiology, Faculty of Life Science, Tokyo University of Agriculture"}]}],"creatorNames":[{"creatorName":"Kaho, Nomura","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yoshifumi, Kimira","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ryosuke, Kobayashi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yuna, Shiobara","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Yoshihiro, Osawa","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Nitta Gelatin Inc.","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Aya, Kataoka-Matsushita","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Jun, Shimizu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Masahiro, Wada","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hiroshi, Mano","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-29"}],"filename":"10283558_出版者版_20240607135008.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://nodai.repo.nii.ac.jp/record/2000281/files/10283558_出版者版_20240607135008.pdf"},"version_id":"8928edda-a405-4795-815c-6a6a25596366"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Collagen-derived dipeptide prolyl-hydroxyproline cooperates with Foxg1 to activate the PGC-1α promoter and induce brown adipocytelike phenotype in rosiglitazone-treated C3H10T1/2 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Collagen-derived dipeptide prolyl-hydroxyproline cooperates with Foxg1 to activate the PGC-1α promoter and induce brown adipocytelike phenotype in rosiglitazone-treated C3H10T1/2 cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["1721958258155"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-29"},"publish_date":"2024-07-29","publish_status":"0","recid":"2000281","relation_version_is_last":true,"title":["Collagen-derived dipeptide prolyl-hydroxyproline cooperates with Foxg1 to activate the PGC-1α promoter and induce brown adipocytelike phenotype in rosiglitazone-treated C3H10T1/2 cells"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2025-06-19T00:50:51.608190+00:00"}